Here is the ultimate universal remote!!! The Logitech Harmony 1000!!! ($499.99)
This 3.5"LCD color touch screen remote can do everything except flush the toilet. Unless you have a wireless toilet flusher. You can set up to 15 components like DVD, computer, TV and etc. However, if you want to lower the cluster of all those components you can get this Wireless Extender ($149.99 pictured below).
Then you can control the devices in multiple rooms because the remote uses radio frequency and infared!! Setup all your components on your PC. This remote supports over 5,000 brands and over 175,000 devices!! And on top of that it is updated daily to support more!!